Cancer Early Detection Advanced Research (CEDAR) center is a collaborative institution within the OHSU Knight Cancer Institute. The Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. At CEDAR our mission is to detect and stop lethal cancers at the earliest stage because early detection saves lives. This is an ambitious goal, one that requires novelty, creativity, and innovation. We are composed of biologists, chemists, biomedical engineers, computationalists, and clinicians conducting groundbreaking translational cancer research to help people maintain a high quality of life and reduce cancer mortality, to create a global early detection community, and to have a positive impact on the Oregon economy.
CEDAR is committed to increasing the diversity of the campus community. We at CEDAR are dedicated to promoting inclusion and multiculturalism to build a successful organization by having outstanding researchers of diverse backgrounds work together on multiple projects. We encourage high-risk, high-reward research projects because defeating cancer requires unproven, out-of-the-box thinking. Our research is milestone driven to ensure that each project is fulfilling its stated goals.
The OHSU Fellowship for Diversity in Research seeks to address the need for increased representation of minoritized races/ethnicities in STEM at the postdoctoral level. Eligible candidates are encouraged to apply. Visit www.ohsu.edu/ofdir for more information.
Every Knight Cancer employee is expected to embody our guiding principles:
We act BOLDLYBreakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
We SUPPORT each otherRespect leads to trust, which leads to excellence
We work as a CONNECTED team We must leverage our collective brain power to conquer cancer because no one individual can do it alone
We are currently hiring a highly motivated fellow with expertise in Quantitative Bioimaging to work in one of the following areas. The successful candidate will be working with CEDAR and OHSU scientists including Xiaolin Nan and Fehmi Civitci initially and with increasing collaborations over time:
Large field superresolution microscopy imaging of tumor cells and tissues. We will develop an imaging and data analysis framework for analyzing tissues and cell populations using large-field superresolution microscopy. The goal is to capture early events in cancer initiation and progression (imaging tissue and tumor models) and to understand the importance of tumor heterogeneity in cancer development and response to therapy;
Multi-omic and multiplexed superresolution imaging of tumor cells and tissues. The emphasis is to extend current fluorescence (such as superresolution microscopy) to a multi-omic analysis tool for studying cancer progression in tissues and tumor models;
High-throughput single-molecule analysis of cancer biomarkers. The goal is to utilize and further develop our high-throughput single-molecule imaging platform for multiplexed cancer biomarker analysis with high sensitivity and specificity.
Lee et al. High-throughput single-particle tracking reveals nested membrane domains that dictates KRasG12D diffusion and trafficking. eLife (2019). http://doi.org/10.7554/eLife.46393
Creech at al. Superresolution imaging of clinical formalin fixed paraffin embedded breast cancer with single molecule localization microscopy. Sci. Rep. (2017). https://doi.org/10.1038/srep40766;
Prepare manuscripts, and present research findings as abstracts or oral presentations (travel may be required)
Attend weekly group meetings and 1:1 meetings to: 1) present data and interpretation of results; 2) troubleshoot research results and 3) suggest next steps
Attend research related meetings including but not limited to Thursday PM SPORE seminars, Cancer Biology meetings, journal clubs
Perform experiments utilizing appropriate lab or computational techniques with proficiency, evaluate results, and determine the next steps to complete project and present data. Think independently and problem solve. Stay on top of the literature and build skills to maximize the projects potential.
Duties as assigned
PhD with major coursework in the one of the following areas: Optics, microscopy, biophysics or related field
Minimum of 3 years as a graduate student
Passion for science and inquiry
Ability to synthesize ones own results and others to formulate hypotheses
Ability to prioritize multiple tasks at one time
Must have excellent communication, analytical and organizational skills: both written and verbal
Ability to work independently and as part of a team while being collaborative in resolving problems
Must be proficient with computers running Windows and PC applications e.g. MS Excel, Oracle, Access, Word and PowerPoint)
Experience with assay or technology development for optical microscopy setups
Experience working with biological samples
Experience with image analysis
Ability to develop new software for hardware control and image analysis
Apply online. To be considered, please be sure to upload a Cover Letter and Resume/CV.
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or firstname.lastname@example.org.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm