Sunovion Pharmaceuticals is looking for a Senior Scientist in Neuroscience to join our Discovery Sciences Department in Marlborough, MA.
As a member of the Discovery Sciences Department, this position will be responsible for designing and managing in vitro and in vivo studies to characterize the biological activity of novel small molecule drug candidates for the treatment of neuropsychiatric and neurological diseases. The position requires broad scientific expertise in the design of studies to examine biochemical pathways and receptor pharmacology and the integration of results to develop neurocircuit & pathway-based hypotheses of drug mechanism of action. Responsibilities include the management of experimental studies conducted through external research partners, as part of our strategy of a flexible business model for drug discovery. The successful candidate will have demonstrated a track record of accomplishments showing successful application of the technical skills required to probe biochemical & pathway effects in experimental systems. Excellent resource management skills and the ability to initiate and maintain effective working relationships with CROs and academic collaborators are essential. This position will work closely with colleagues in medicinal chemistry, safety/toxicology and translational medicine and development and may also lead discovery projects/initiatives.
Applies technical expertise to design & conduct studies to support the development of novel small molecules for psychiatric and neurological conditions. Develops mechanistic hypotheses and delivers research results to enhance understanding of mechanism of action & effects on biochemical pathways/circuits. May lead discovery projects/initiatives.
Manages external relationships with CROs, research partners and academic institutions to deliver high impact pharmacology results. Manages research related documentation including study plans, data files and scientific reports supporting regulatory filings. Seeks and develops new external relationships to apply new technologies to CNS discovery programs.
Works in project teams with medicinal chemists, pharmacologists, preclinical safety and translational medicine scientists to advance novel agents into development. Communicates research results to internal and external stakeholders including collaborators, key opinion leaders and partners at Sumitomo Dainippon Pharma.
Minimum Education, Experience, Knowledge and Skills Required:
PhD in Pharmacology, Neuroscience or related field with 3-5 years post-doctoral experience.
At least 3 years post-doctoral research experience in neuroscience research.
Expert in the technical application of biochemistry and receptor pharmacology techniques such as the following: radioligand binding, receptor functional assays, signaling pathways, Western blots, ELISA, neuronal cell cultures systems.
Experience with biochemical pathway analysis tools and techniques used to develop mechanistic hypotheses of drug action eg genomics, RNAseq, (phospho)proteomics desirable.
Knowledgeable in other in vitro/ex vivo techniques eg electrophysiology and able to utilize a wide range of in vitro/ex vivo technique to develop successful research strategies to probe mechanism of action.
Demonstrated record of accomplishments showing technical & research accomplishments and the ability to work collaboratively with external organizations.
Ability to work on computers for extended periods, robust data analysis skills and proficiency with professional software and statistical and pathways analysis tools are required (e.g. MATLAB, R, Python, etc.).
Must have excellent oral and written communication skills and an innovative spirit with capacity for generating new ideas.
Internal Number: R00239
About Sunovion Pharmaceuticals, Inc.
Lead the way to a healthier world by putting patients at the center of everything we do.
We are focused on developing innovative therapies and transforming the lives of people with serious medical conditions. We are creating innovative psychiatric, neurological and respiratory therapies that help transform people's lives, while at the same time we are playing an increasingly active role in the future of global health.